I’ve been delving into the effects of methotrexate, particularly concerning its use during pregnancy. It’s well-documented that high doses of this medication, often used in chemotherapy, significantly increase the risk of adverse pregnancy outcomes. However, even at lower doses, typically administered for autoimmune diseases, there seems to be a link to increased rates of miscarriage. There also remains an unclear risk regarding potential birth defects.
Given these risks, medical guidelines generally advise against the use of methotrexate during pregnancy. The decision brings to light the critical need for healthcare providers and patients to carefully consider the implicatoins of treatments affecting fertility and prenatal health.