I’ve looked into PDE5 inhibitors quite a bit myself, and here’s what I can share. The main ones—sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and avanafil (Stendra)—each have unique profiles. Sildenafil and vardenafil typically work within 30-60 minutes and last around four to six hours, while tadalafil can last up to 36 hours, which some find more convenient. Avanafil acts quicker, often within 15 minutes. As for side effects, headaches, facial flushing, and indigestion are common, though some folks mention rare issues like blue-tinted vision or muscle aches, more so with sildenafil.
In terms of new research, there’s ongoing work exploring how these drugs might also benefit heart health. Recently, studies have looked at combining PDE5 inhibitors with other treatments, aiming for enhanced effectiveness. It’s worth noting individual response can vary, so trying a few might be necessary. Have you spoken to a healthcare provider about which might suit your lifestyle best?