You’ve already covered the greatest hits—nerve damage and blood vessel issues—but diabetes is annoyingly thorough. High blood sugar loves to mess with hormone levels (testosterone, anyone?) and can cause stress, fatigue, and even mess with your mood, all of which can put the brakes on your bedroom ambitions. Plus, a lot of the meds for diabetes and related conditoins (like blood pressure meds) aren’t exactly known for helping things in that department. Basically, diabetes is a multi-talented party crasher when it comes to ED.