Platelet-Rich Plasma (PRP) for Erectile Dysfunction: Experiences and Evidence?
I am interested in reviewing the current clinical evidence and real-world experiences with platelet-rich plasma (PRP) injections for erectile dysfunction (ED). The mechanism of action is said to involve growth factors released from platelets that may enhance tissue regeneration, angiogenesis, and nerve healing within the corpus cavernosum.
Existing literature includes several small-scale studies and case series, but randomized controlled trials (RCTs) with standardized protocols appear limited. Some publications report improvements in the International Index of Erectile Function (IIEF) scores and penile hemodynamics, while others highlight methodological concerns, small sample sizes, and placebo effects.
Has anyone in this forum undergone PRP therapy for ED, either as a standalone or adjunct treatment? If so, could you detail your treatment protocol (number and frequency of injections, PRP preparation method, adjunctive therapy, etc.), subjective outcomes, side effects, and duration of response?
Additionally, I would appreciate discussion of the following:
- Any notable adverse events unique to PRP for ED
- Comparative efficacy versus established therapies such as PDE5 inhibitors or intracavernosal injections
- The regulatory status and quality control regarding PRP preparation
- Data on long-term efficacy and need for repeat treatments
A critical synthesis of published data and personal experiences would be valuable for practitioners and patients considering this emerging modality.