I went down this rabbit hole recently and found a few nuggets that helped me make sense of the mixed stories:
- Big picture: meta-analyses show a small but real average bump in erectile function scores on statins (about +3-4 IIEF points) within 1-3 months, likely from better endothelial nitric oxide. Not everyone feels it, but it’s not all doom and gloom.
- Testosterone: pooled data shows a slight drop in total T on average, with little to no change in free T or symptoms. If numbers tank or you feel hypogonadal, that’s a flag to look for another cause or adjust meds.
- Hydrophilic vs lipophilic: no consistent winner, but if you’re sensitive, rosuvastatin or pravastatin (more hydrophilic) are the usual “try next” options. Alternate‑day rosuvastatin is a common workaround.
- Dose strategy: if libido/erections dip on high‑intensity, stepping to moderate‑intensity and adding ezetimibe often hits LDL targets with fewer side effects. PCSK9s are another LDL hammer if needed.
- Timing: matters for short half‑life agents (simvastatin tends to be night), otherwise doesn’t seem to affect libido or sleep in any consistent way.
- CoQ10: can help statin myalgias; not great evidence it fixes sexual side effects.
- PDE5s: safe with statins. Response can improve as lipids/endothelium improve; daily low‑dose tadalafil (5 mg) is a nice bridge.
- BP meds: thiazides and older beta‑blockers can drag erections; ARBs/ACEi are neutral or positive; nebivolol is the most ED‑friendly beta‑blocker.
- Objective data: small studies show improved penile peak systolic velocity after a few months of statin in dyslipidemic guys.
If it were me talking with a clinician: baseline and 8-12 week check on lipids, A1c, TSH, total/free T + SHBG; review other meds (SSRIs, finasteride, antihypertensives); if issues, trial a switch to rosuvastatin/pravastatin or alternate‑day dosing, and consider adding ezetimibe rather than pushing dose. Meanwhile, PDE5s can keep confidence up while the vascular benefits of the statin kick in.